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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
34.24
Human Site:
T1224
Identified Species:
53.81
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
T1224
Q
R
V
I
P
R
I
T
I
E
M
K
A
E
A
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1255
R
R
I
I
P
E
I
T
A
M
K
A
D
A
S
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1241
R
R
V
I
P
E
I
T
A
M
K
A
D
A
S
Dog
Lupus familis
XP_537646
1532
174610
T1224
K
R
V
I
P
R
V
T
I
E
M
K
A
E
A
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
T1222
K
R
V
I
P
Q
V
T
V
E
M
K
A
E
A
Rat
Rattus norvegicus
P41516
1526
173202
T1221
K
R
V
I
P
Q
V
T
M
E
M
R
A
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
T1255
R
R
V
I
P
R
V
T
I
E
M
K
A
E
A
Chicken
Gallus gallus
O42130
1553
174974
T1225
I
R
V
V
P
R
V
T
A
E
M
K
A
E
A
Frog
Xenopus laevis
NP_001082502
1579
178601
T1219
R
R
V
I
P
R
V
T
T
A
M
K
E
E
A
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
T1221
R
R
V
I
P
R
I
T
S
T
M
K
V
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
L1156
K
L
S
E
L
E
S
L
R
K
K
T
P
E
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
L1219
Q
D
L
W
H
E
D
L
D
N
F
V
S
E
L
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
L1156
N
Y
L
L
G
M
S
L
W
S
L
T
K
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
K1172
S
L
D
K
E
L
E
K
L
D
L
K
D
A
Q
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
E1138
K
L
L
K
Q
K
Q
E
K
E
T
E
L
E
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
33.3
40
86.6
N.A.
73.3
66.6
N.A.
86.6
73.3
66.6
66.6
N.A.
6.6
N.A.
13.3
6.6
P-Site Similarity:
100
53.3
53.3
100
N.A.
100
100
N.A.
100
86.6
80
80
N.A.
20
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
20
7
0
14
40
20
54
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
0
0
7
0
7
7
0
0
20
0
0
% D
% Glu:
0
0
0
7
7
27
7
7
0
47
0
7
7
74
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
7
60
0
0
27
0
20
0
0
0
0
0
0
% I
% Lys:
34
0
0
14
0
7
0
7
7
7
20
54
7
0
7
% K
% Leu:
0
20
20
7
7
7
0
20
7
0
14
0
7
0
7
% L
% Met:
0
0
0
0
0
7
0
0
7
14
54
0
0
0
7
% M
% Asn:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% N
% Pro:
0
0
0
0
67
0
0
0
0
0
0
0
7
0
0
% P
% Gln:
14
0
0
0
7
14
7
0
0
0
0
0
0
7
7
% Q
% Arg:
34
67
0
0
0
40
0
0
7
0
0
7
0
0
0
% R
% Ser:
7
0
7
0
0
0
14
0
7
7
0
0
7
0
14
% S
% Thr:
0
0
0
0
0
0
0
67
7
7
7
14
0
0
0
% T
% Val:
0
0
60
7
0
0
40
0
7
0
0
7
7
0
0
% V
% Trp:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _